One of the best tools for your GrapheneOS

Rethink DNS + Firewall + VPN for Android

A WireGuard client, an OpenSnitch-inspired firewall and network monitor + a pi-hole-inspired DNS over HTTPS client with blocklists.

You can open one than more VPN connection at the same time, can configure which app uses which VPN connection, run Orbot as proxy etc.

When you use it with black and whitelists it acts like a local PiHole on GOS

https://github.com/celzero/rethink-app

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Discussion

You can already have 3 VPNs at the same time, using the main profile + work profile + private space, on top of using apps with internal Tor.

Yes, possible. I run it in one profile and the beauty is the DNS Black / Whitelist feature like a local PiHole on your phone and that you can choose which app uses which VPN or no VPN and with the firewall you have a lot more options like bypass all rules or block access only for WiFi connections for a specific app etc.