Anti-Aging Pill for Dogs Clears Key FDA Hurdle
San Francisco-based biotech startup Loyal says a drug it developed to increase dogs' lifespan "has passed a significant milestone on the way to regulatory approval," reports the Washington Post:
The Food and Drug Administration certified the daily pill as having a "reasonable expectation of effectiveness" at extending senior dogs' lifespans. The regulator's Center for Veterinary Medicine still has to certify that the drug is safe and that Loyal can manufacture it at scale before vets can prescribe the pill to dogs 10 years or older that weigh 14 pounds or more. Loyal's CEO, Celine Halioua, estimates that the process should be complete by the end of 2025 and called the FDA's initial recognition "a key step" to extending dogs' lives...
In the past decade, a subculture of tech entrepreneurship has focused on helping people stave off death, hawking custom-made dietary supplements and $2,500 full-body MRIs and investing in the development of antiaging drugs, among many other efforts. According to data firm Pitchbook, about $900 million in venture capital has been poured into antiaging and longevity start-ups in the past 12 months. Loyal has raised more than $150 million in venture funding since its 2019 founding to develop lifespan-extending drugs initially focused on canines.
Launching veterinary drugs is in some ways easier than winning approval for human treatments. Because dogs and humans have evolved alongside one another, Halioua hopes to eventually apply her findings about pets to help prolong their owners' lives. "If we can successfully delay the onset and severity of age-related diseases in dogs, it's extremely compelling evidence that it will also do that in humans," Halioua said. The biological processes of aging unfold faster in dogs because they live such short lives, she said, helping researchers and entrepreneurs probe how they work.
"Loyal's pill is a result of research into how to mimic the life-extending benefit of caloric restriction without the appetite suppression," according to the article, "and without the need for an owner to restrict their dog's food.
"The drug aims to improve a dog's metabolic fitness, or the body's ability to convert nutrients into energy and regulate hormones, which declines in humans and canines with age..."
at Slashdot.
Google's Sergey Brin Urges Workers To the Office at Least Every Weekday
Google co-founder Sergey Brin has urged employees working on the company's Gemini AI products to be in the office "at least every weekday" [non-paywalled source] and suggested "60 hours a week is the sweet spot of productivity," according to an internal memo cited by The New York Times. The directive comes as Brin warned that "competition has accelerated immensely and the final race to A.G.I. is afoot," referring to artificial general intelligence, when machines match or surpass human intelligence.
"I think we have all the ingredients to win this race, but we are going to have to turbocharge our efforts," Brin wrote in the Wednesday evening memo. The guidance does not alter Google's official policy requiring employees to work in-office three days weekly. Brin, who returned to Google following ChatGPT's 2022 launch, also criticized staff who "put in the bare minimum," calling them "highly demoralizing to everyone else."
at Slashdot.
US Workers See AI-Induced Productivity Growth, Fed Survey Shows
Workers reported saving a substantial number of work hours by using generative AI, according to research conducted by the Federal Reserve Bank of St. Louis, along with Vanderbilt and Harvard universities. From a report: The researchers, drawing from what they identified as the first nationally representative survey of generative AI adoption, measured the impact of generative AI on work productivity by how much workers used the technology and how intensely. They found users are saving meaningful amounts of time.
"On average, workers are 33% more productive in each hour that they use generative AI," the paper found. Among respondents that used generative AI in the previous week, 21% said it saved them four hours or more in that week, 20% reported three hours, 26% said two hours and 33% reported an hour or less.
at Slashdot.
The Reality of Long-Term Software Maintenance
When developers boast "I could write that in a weekend," they're missing the painful reality that haunts software maintainers for years. In a candid blog post, Construct developer Ashley explains why maintaining large software projects is a burden most programmers fail to appreciate. "Writing the initial code for a feature is only a fraction of the work," Ashley explains, estimating it represents just "25% of the total work" in Construct's 750,000-line codebase. The rest? A grinding cycle of "testing, diagnosing and fixing bugs, optimizing performance, upgrading it to work with other changes, refactoring, customer support, writing documentation and similarly revising the documentation over time."
Ashley describes how accepting code contributions feels like someone offering to build you a free extension -- initially attractive until the roof starts leaking years later and the original builder is nowhere to be found. Meanwhile, your tenants (users) are furious, and you're stuck with "no good options." The post recounts Construct's own bruises: a community-contributed storage plugin still causing compatibility headaches a decade later, and third-party libraries that became maintenance nightmares after their creators vanished.
These experiences explain why seasoned maintainers eye large code contributions with deep suspicion rather than gratitude. "If you suggest some software project uses some code -- even a small amount -- will you be there in literally 10 year's time sorting out all the issues that arise from it?" Ashley asks. "Usually the answer is no."
at Slashdot.
Electronic Devices Used For Car Thefts Set To Be Banned in England
Sophisticated electronic devices used by criminals to steal cars are set to be banned under new laws in England and Wales. From a report: More than 700,000 vehicles were broken into last year -- often with the help of high-tech electronic devices, including so-called signal jammers, which are thought to play a part in four out of 10 vehicle thefts nationwide.
Until now, police could only bring a prosecution if they could prove a device had been used to commit a specific offence, but under new laws in the Crime and Policing Bill the onus will be on someone in possession of a device to show they had it for a legitimate purpose. Making or selling a signal jammer could lead to up to five years in prison or an unlimited fine.
at Slashdot.
Fruits and Flowers May Counteract Harmful Effects of Microplastics
New research suggests that anthocyanins, the antioxidants responsible for the vibrant colors of fruits and flowers, may help counteract reproductive harm caused by microplastics. The Guardian reports: The new review of scientific literature on anthocyanins found that the compounds are probably protective against a range of plastic-induced impacts on hormones, reductions in testosterone and estrogen, decreased sperm counts, lower sperm quality, erectile dysfunction and ovarian damage. [...] Researchers said that mice exposed to microplastics, then treated with anthocyanins, showed increased sperm quality, including increased sperm count and motility, and the antioxidants overall reduced testicular damage. The new paper also pointed to research that found some microplastics reduce testosterone levels because they harm Leydig cells, which are responsible for the hormone's production. Anthocyanins seem to helped restore testosterone production and protect Leydig cells.
In women, impacts on fertility and sexual development could be mitigated by anthocyanins that seem to protect hormone receptors from plastic chemicals such as bisphenol, phthalates and cadmium. The chemicals can mimic hormones, or cause hormonal responses. Microplastics in ovarian tissue cause inflammation that seems to lower levels of estrogen and other hormones. Research found that treating rats exposed to microplastics protected the ovarian tissue and normalized levels of estrogen and other hormones. "Its antioxidant properties help preserve ovarian function and potentially maintain fertility, highlighting its therapeutic potential in managing ovarian damage," the authors wrote.
at Slashdot.
Earth Safe From 'City-Killer' Asteroid 2024 YR4
Asteroid 2024 YR4, once considered a significant impact risk, has been reassigned to Torino Scale Level Zero and therefore poses no hazard to Earth. "The NASA JPL Center for Near-Earth Object Studies (CNEOS) now lists the 2024 YR4 impact probability as 0.00005 (0.005%) or 1-in-20,000 for its passage by Earth in 2032," Richard Binzel, Professor of Planetary Science at the Massachusetts Institute of Technology (MIT) and creator of the Torino scale exclusively told Space.com. "That's impact probability zero folks!" From the report: Discovered in Dec. 2024, 2024 YR4 quickly climbed to the top of NASA's Sentry Risk table, at one point having a 1 in 32 chance of hitting Earth. This elevated it to Level 3 on the Torino scale, a system used since 1999 to categorize potential Earth impact events. Level 3, which falls within the yellow band of the Torino Scale, is described as: "A close encounter, meriting attention by astronomers. Current calculations give a 1% or greater chance of collision capable of localized destruction."
This conforms to the second part of the Torino scale level 3 description, which states: "Most likely, new telescopic observations will lead to re-assignment to Level 0. Attention by public and by public officials is merited if the encounter is less than a decade away." "Asteroid 2024 YR4 has now been reassigned to Torino Scale Level Zero, the level for 'No Hazard' as additional tracking of its orbital path has reduced its possibility of intersecting the Earth to below the 1-in-1000 threshold," Binzel continued. "1-in-1000 is the threshold established for downgrading to Level 0 for any object smaller than 100 meters; YR4 has an estimated size of 164 feet (50 meters)."
[...] While 2024 YR4 poses no threat, it will still have a major scientific impact when it passes Earth in 2028 and again in 2032. On Dec. 17, the asteroid will come to within 5 million miles of Earth. Then, on Dec.22, 2032, 2024 YR4 will pass within just 167,000 miles of our planet. For context, the moon is 238,855 miles away.
at Slashdot.
Global Sales of Combustion Engine Cars Have Peaked
Our World in Data: To decarbonize road transport, the world must move away from petrol and diesel cars and towards electric vehicles and other forms of low-carbon transport.
This transition has already started. In fact, global sales of combustion engine cars are well past the peak and are now falling.
As you can see in the chart, global sales peaked in 2018. This is calculated based on data from the International Energy Agency. Bloomberg New Energy Finance estimates this peak occurred one year earlier, in 2017.
Sales of electric cars, on the other hand, are growing quickly.
at Slashdot.
1,000 Artists Release 'Silent' Album To Protest UK Copyright Sell-Out To AI
An anonymous reader quotes a report from TechCrunch: The U.K. government is pushing forward with plans to attract more AI companies to the region through changes to copyright law that would allow developers to train AI models on artists' content on the internet -- without permission or payment -- unless creators proactively "opt out." Not everyone is marching to the same beat, though. On Monday, a group of 1,000 musicians released a "silent album," protesting the planned changes. The album -- titled "Is This What We Want?" -- features tracks from Kate Bush, Imogen Heap, and contemporary classical composers Max Richter and Thomas Hewitt Jones, among others. It also features co-writing credits from hundreds more, including big names like Annie Lennox, Damon Albarn, Billy Ocean, The Clash, Mystery Jets, Yusuf / Cat Stevens, Riz Ahmed, Tori Amos, and Hans Zimmer.
But this is not Band Aid part 2. And it's not a collection of music. Instead, the artists have put together recordings of empty studios and performance spaces -- a symbolic representation of what they believe will be the impact of the planned copyright law changes. "You can hear my cats moving around," is how Hewitt Jones described his contribution to the album. "I have two cats in my studio who bother me all day when I'm working." To put an even more blunt point on it, the titles of the 12 tracks that make up the album spell out a message: "The British government must not legalize music theft to benefit AI companies." [...] The solution, say the artists, is to produce work in other markets where there might be better protections for it. Hewitt Jones -- who threw a working keyboard into a harbor in Kent at an in-person protest not long ago (he fished it out, broken, afterwards) -- said he's considering markets like Switzerland for distributing his music in the future.
at Slashdot.
Ellison's Half-Billion-Dollar Quest To Change Farming Has Been a Bust
Oracle founder Larry Ellison's agricultural technology venture Sensei Ag has largely failed to deliver on its ambitious goals despite costing more than half a billion dollars, more than he spent to purchase Hawaii's Lanai island itself. Eight years after its founding, little of the revolutionary technology Sensei promised - including AI crop breeding, robotic harvesting, and advanced sensors - is being utilized in its six greenhouses on Lanai, according to WSJ.
The company has faced numerous setbacks, including greenhouses that weren't built to withstand Lanai's strong winds, solar panels that malfunctioned, and executives with limited agricultural experience. Far from its original mission to "feed the world," Sensei currently grows lettuce and cherry tomatoes primarily for Hawaii's local market, while its Canadian operations supply some East Coast supermarkets. The company has pivoted to focus on developing software and robotics at test centers in Southern California, aiming to eventually license technology packages to other indoor farms.
at Slashdot.
Should Climate Change Be Acknowledged In Movies?
The Los Angeles Times publishes a weekly "Boiling Point" newsletter about climate change and energy issues. And this week they examined whether the scientific fact of a change climate is reflected in the mass media:
For the second year running, nonprofit consulting firm Good Energy applied its Climate Reality Check to the actual Oscar-nominated films [which] tests whether a movie and its characters acknowledge global warming... Of last year's 13 Oscar-nominated films that met Good Energy's criteria (feature-length movies set in present-day or near-future Earth) three passed the test. This year, there were 10 eligible films. Only "The Wild Robot" passed...
Maybe a few years from now, studios will release a torrent of movies and shows reflecting the realities of a scary-but-still-salvageable world, helmed by producers and writers jolted into renewed awareness by the infernos. But for now, the picture is bleak. A peer-reviewed study slated for publication this month, led by Rice University English and environmental studies professor Matthew Schneider-Mayerson, analyzes climate change mentions in 250 of the most popular movies of the last decade. The authors found that just 12.8% of the films allude to global warming. Just 3.6% depict or mention the climate crisis in two or more scenes. "A lot of times, it's really being mentioned in passing," Schneider-Mayerson said...
[Good Energy Chief Executive Anna Jane Joyner] pointed to another analysis led by Schneider-Mayerson, which found that movies passing the Climate Reality Check and released in theaters earned 10% more at the box office, on average, than films failing the test. Netflix, meanwhile, says on its website that 80% of its customers "choose to watch at least one story on Netflix that helps them better understand climate issues or highlight hopeful solutions around sustainability...." [Netflix's "Sustainability Stories" collection includes Dr. Seuss' The Lorax, Chicken Run: Dawn of the Nugget, and Waterworld]
Sponsors are interested in selling audiences on climate-friendly products, too. I was sitting in a movie theater last weekend enjoying "Captain America: Brave New World" — the latest entry in Disney's Marvel Cinematic Universe — when, to my surprise, Sam Wilson (Anthony Mackie) got out of his SUV and pulled his iconic red-white-and-blue shield out of the front trunk. Yes, a front trunk, where an internal combustion engine would normally be. That meant Captain America was driving an electric vehicle, right? Indeed, he was. I did some research after I got home and learned that Wilson was driving a GMC Hummer EV, the result of a paid partnership between Marvel Studios and GMC parent company General Motors.
Ironically, the movie does not at any point acknowledge global warming, the article points out (adding "Also, SUVs kill more pedestrians and cyclists than smaller cars.")
"But the more movies and TV shows spotlight climate solutions — electric vehicles, solar panels, induction stoves — the more likely people are to support those solutions. For Hollywood, that's a step in the right direction."
at Slashdot.
Fedora Amicably Resolves Legal Threat From OBS Studio Over Downstream Flatpak
When it comes to application packaging, earlier this month the site Its FOSS complained that Fedora Flatpaks "are often unmaintained or broken, leading to a poor experience for users who aren't usually aware they're using them." And this apparently created friction with OBS Studio, the free/open-source screencasting and streaming app.
"We are now considering the Fedora Flatpaks distribution of OBS Studio a hostile fork," OBS Studio lead Joel Bethke posted in on GitLab's page for Fedora Flatpaks. They said they were making "a formal request to remove all of our branding, including but not limited to, our name, our logo, any additional IP belonging to the OBS Project, from your distribution. Failure to comply may result in further legal action taken...." (Issues with Fedora's packaging led "to users complaining upstream thinking they are being served the official package..." Bethke said in his original Issue. "I would also like some sort of explanation on why someone thought it was a good idea to take a Flatpak that was working perfectly fine, break it, and publish it at a higher priority to our official builds.")
23 people clicked "Like" on the original Issue — but threatening legal action only happened after Bethke felt Fedora was unresponsive, according to It's FOSS:
In a comment on a video by Brodi Robertson (check pinned comment), Joel shared that folks from Fedora were not taking this issue seriously, with one of them even resorting to name-calling by labeling the OBS Studio devs as being "terrible maintainers". Since then, a major step has been taken by Neal Gompa, a well-known Fedora contributor and member of the Fedora Engineering Steering Committee (FESCo). He has opened a new issue to remove Fedora's OBS Studio flatpak from the registry as soon as possible.
But by Tuesday Bethke posted in a new comment on GitLab announcing that "a very good conversation" with the Flatpak SIG and Fedora Project Leader seemed to have cleared the tension. "We discussed the issues, how we got here, and what next steps are... [T]he OBS Project is no longer requesting a removal of IP or rebrand of the OBS Studio application provided by Fedora Flatpaks." To the issue of not knowing where to report bugs for the downstream package, "We had some very good discussion on how this might be accomplished in the medium-long term, but don't consider it a blocker at this point." As for other issues with Fedora's Flatpak for OBS Studio, "The discussion was positive and they are actively working to resolve..."
And similar sentiments were echoed on Fedora's own issue tracker. "We had a good conversation today, and there is a hopeful path forward that does not require the OBS Project distancing itself from Fedora Flatpaks..."
at Slashdot.
Unexpected Shape of Lead-208 Nucleus of May Force Scientists to Reevaluate Atomic Nuclei Models
"An international research collaboration led by the University of Surrey's Nuclear Physics Group has overturned the long-standing belief that the atomic nucleus of lead-208 is perfectly spherical," reports Phys.org.
They add that the discovery "challenges fundamental assumptions about nuclear structure and has far-reaching implications for our understanding of how the heaviest elements are formed in the universe..."
[A] new study published in Physical Review Letters used a high-precision experimental probe to examine its shape and found that rather than being perfectly spherical, the nucleus of lead-208 is slightly elongated, resembling a rugby ball (prolate spheroid)... Using the state-of-the-art GRETINA gamma-ray spectrometer at Argonne National Laboratory in Illinois, U.S., scientists bombarded lead atoms with high-speed particle beams accelerated to 10% of the speed of light — equivalent to circling the Earth every second. The interactions created unique gamma-ray fingerprints of the properties of excited quantum states in lead-208 nuclei — in other words, the nuclei were energized — which, in turn, were used to determine its shape.
Theoretical physicists, including those at the Surrey Nuclear Theory Group, are now re-examining the models used to describe atomic nuclei, as the experiments suggest that nuclear structure is far more complex than previously thought.
at Slashdot.
Lithium Batteries Reignited Tuesday at the Moss Landing Power Plant Fire Site
Remember that battery plant fire last month in Moss Landing, California? Tuesday night local firefighters "determined that a group of lithium batteries in an area that had previously burned during the January 16 fire had smoldered and reignited," reports SFGate.
Fire Chief Joel Mendoza said the flames burned at varying intensities throughout Tuesday night before the fire burned itself out at about 8 a.m. on Wednesday.
Additional flare-ups at the site are expected due to weather exposure and damage to the remaining batteries. "Rekindling is very, very likely — almost a certainty," said EPA onsite coordinator Eric Sandusky, adding that rain and humidity can interact with the damaged batteries, leading to short circuits and reignition. To further reduce fire risk, Sandusky said the EPA is working with Vistra to begin "de-linking the batteries," a process that disconnects them to lower the risk of propagation and prevent a large-scale fire...
"Vistra said that since the January 16 fire, they have brought in a private fire crew that is on-site at all times to monitor the Moss 300 building," according to a local news site.
Fire Chief Joel Mendoza shared more details with the digital newspaper Lookout Santa Cruz. "We've been saying all along that batteries exposed to heat that didn't burn can ignite. We were hoping that it wouldn't happen, but it did."
at Slashdot.
California Sues Data-Harvesting Company NPD, Enforcing Strict Privacy Law
California sued to fine a data-harvesting company, reports the Washington Post, calling it "a rare step to put muscle behind one of the strongest online privacy laws in the United States."
Even when states have tried to restrict data brokers, it has been tough to make those laws stick. That has generally been a problem for the 19 states that have passed broad laws to protect personal information, said Matt Schwartz, a policy analyst for Consumer Reports. He said there has been only 15 or so public enforcement actions by regulators overseeing all those laws. Partly because companies aren't held accountable, they're empowered to ignore the privacy standards. "Noncompliance is fairly widespread," Schwartz said. "It's a major problem."
That's why California is unusual with a data broker law that seems to have teeth. To make sure state residents can order all data brokers operating in the state to delete their personal records [with a single request], California is now requiring brokers to register with the state or face a fine of $200 a day. The state's privacy watchdog said Thursday that it filed litigation to force one data broker, National Public Data, to pay $46,000 for failing to comply with that initial phase of the data broker law. NPD declined to comment through an attorney... This first lawsuit for noncompliance, Schwartz said, shows that California is serious about making companies live up to their privacy obligations... "If they can successfully build it and show it works, it will create a blueprint for other states interested in this idea," he said.
Last summer NPD "spilled hundreds of millions of Americans' Social Security Numbers, addresses, and phone numbers online," according to the blog Krebs on Security, adding that another NPD data broker sharing access to the same consumer records "inadvertently published the passwords to its back-end database in a file that was freely available from its homepage..."
California's attempt to regulate the industry inspired the nonprofit Consumer Reports to create an app called Permission Slip that reveals what data companies collect and, for people in U.S. states, will "work with you to file a request, telling companies to stop selling your personal information."
Other data-protecting options suggested by The Washington Post:
Use Firefox, Brave or DuckDuckGo, "which can automatically tell websites not to sell or share your data. Those demands from the web browsers are legally binding or will be soon in at least nine states."
Use Privacy Badger, an EFF browser extension which the EFF says "automatically tells websites not to sell or share your data including where it's required by state law."
at Slashdot.
ArcaOS (OS/2 Warp OEM) 5.1.1 Has Been Released
"IBM stopped supporting OS/2 at the end of 2006," write the makers of ArcaOS, an OEM distribution of OS/2's discontinued Warp operating system.
And now long-time Slashdot reader martiniturbide tells us that ArcaOS 5.1.1 has been released, and that many of it's components have been updated too. From this week's announcement:
ArcaOS 5.1.1 continues to support installation on the latest generation of UEFI-based systems, as well as the ability to install to GPT-based disk layouts. This enables ArcaOS 5.1.1 to install on a wide array of modern hardware. Of course, ArcaOS 5.1.1 is just as much at home on traditional BIOS-based systems, offering enhanced stability and performance across both environments....
Need more convincing? How about a commercial operating system which doesn't spy on you, does not report your online activity to anyone, and gives you complete freedom to choose the applications you want to use, however you want to use them? How about an operating system which isn't tied to any specific hardware manufacturer, allowing you to choose the platform which is right for you, and fits perfectly well in systems with less than 4GB of memory or even virtual machines?
at Slashdot.
HP Deliberately Adds 15 Minutes Waiting Time For Telephone Support Calls
HP will impose a minimum 15-minute wait time for consumer PC and printer support calls in five European countries, seeking to push customers toward digital channels, according to internal documents seen by The Register. The policy, implemented February 18, affects retail customers in Britain, Ireland, France, Germany and Italy. The outlet added that it anticipates "more countries could be added."
at Slashdot.
Rare Genetic Disorder Treated in Womb For the First Time
A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. Nature: The child's mother took the gene-targeting drug during late pregnancy, and the child continues to take it. The "baby has been effectively treated, with no manifestations of the condition," says Michelle Farrar, a paediatric neurologist at UNSW Sydney in Australia. The results were published in the New England Journal of Medicine yesterday. The child was conceived with a genetic condition known as spinal muscular atrophy, which affects motor neurons that control movement, and leads to progressive muscle weakening.
About one in every 10,000 births have some form of the condition -- making it a leading genetic cause of death in infants and children. In its most severe form, as in the case of this child, individuals lack both copies of the SMN1 gene, and have only one or two copies of a neighbouring gene, SMN2, that partially compensates for that deficiency. As a result, the body does not produce enough of the protein required for maintaining motor neurons in the spinal cord and brainstem. This protein is most important in the second and third trimesters, and the first few months of life. Babies with severe disease don't usually live past their third birthday.
at Slashdot.
Amazon To Shut Down Android Appstore
Amazon will discontinue its Android Appstore servicefrom August 20, 2025, ending its decade-long attempt to compete with Google's Play Store in the Android mobile ecosystem. The Amazon Appstore, launched in 2011, served as an alternative marketplace for Android users to download apps. The platform gained prominence in 2012 when Amazon began using it as the primary app store for its Kindle Fire tablets.
at Slashdot.
Microsoft Declutters Windows 11 File Explorer in the Name of Euro Privacy
Microsoft will strip several features from Windows 11's File Explorer for European users to comply with privacy regulations, the company says. The changes, affecting Entra ID accounts in the European Economic Area, remove Recent, Favorites, Details Pane, and Recommended content sections that previously tracked user activity.
These features relied on collecting user data to display recently accessed files and personalized recommendations. The privacy-focused update, part of Windows 11 preview build 26120.3281, results in a streamlined File Explorer interface.
at Slashdot.