#Signet Saturday is off to a start, and I'm confirming parts of my hypothesis. Just confirmed that #Tails 5.17.1 has the same issue as #Qubes 4.2 with hidraw devices on my newest motherboard.
This is the second motherboard to have this issue, and they were different makes and models, so this seems to point to a software issue. The good news is that this is something for which I'm more likely to be able to find a fix or workaround.