Tbh, I've watched this before when learning about the blocksize war... Rewatching it doesn't make me think I won't be able to run a node or wouldn't want to do it in 50 years.
I think the biggest obstacle in running a node will always be the learning. If somebody can give me a practical reason why I won't be able to, or why bitcoin will stop working - and I'm living in very suboptimal circumstances in a western country - I'll start to worry about this myself.
As far as I can tell, and without having experienced any economic benefit of holding bitcoin yet, nothing is stopping me from running a node for the next 100 years in my current circumstances.
