Yes. If there isn't enough outgoing liquidity along the paths to the node you are paying, the payment will fail. This often happens when people have a small number of channels with relatively small pleb nodes. The path to the destination might be circuitous with a bottleneck of liquidity along the way.
Discussion
So interesting. When I set up this lightning node I rushed to get a bunch of smallish channels quickly from amboss.
Right now there’s like 50k sats total that are stuck on these small channels - would best thing to do is wait and try again hoping some liquidity is added?
I might consider closing all channels while fees are cheap, and pool your liquidity into one channel with a very well-connected node. Going forward, maybe stack a little more before establishing larger channels. Small public channels don't really do anyone any good.