the dopamine hypothesis of addiction is wrong

it's about insulin and blood sugar

alcohol and cannabis increase insulin response, caffeine (via paraxanthine) increases conversion of fats into blood sugar, i know there is definitely a big role of blood glucose regulation with methamphetamine, and i found that after about 24 hours (and fasting, obviously) it changed my metabolism in a way that helped me think clearer, though continuing to dose after that point leads to a slow crash of blood sugar that you can tell is happening because your body gets colder and you can't think properly... most likely cocaine has a substantial effect on blood sugar too, it's just a drug i've rarely taken because for me it is worse than too much alcohol and too much amphetamine at the same time, the hangover is horrendous

all of these are addictive drugs, all have notable effects on sugar metabolism

it's not and never has been about dopamine, it's about blood sugar