Research explores how the antidepressant fluoxetine protects against sepsis through immunometabolic mechanisms, finding it promotes both resistance and cooperative host defenses independent of serotonin. The study reveals fluoxetine increases IL-10 levels which prevents cardiac dysfunction and regulates lipid metabolism during infection.

https://www.science.org/doi/10.1126/sciadv.adu4034

#immunology #pharmacology #metabolism #sepsis #drugresearch