I have done ayahuasca. Its reputation for inducing nausea is well-deserved. If you ever try it, be sure to avoid tyramine-rich foods for a day or so afterward. The monoamine oxidase inhibitor (MAOI) component of ayahuasca makes tyramine dangerous.
https://www.mayoclinic.org/diseases-conditions/depression/expert-answers/maois/faq-20058035