Gossip on desktop. It's different than most mobile-friendly clients, but it works so well. https://github.com/mikedilger/gossip
Someone mentioned coracle.social uses it as well, but I'm not sure about that.
Discussion
I’ve heard good things about it. If I was at my computer more I would bother to set it up. For me it has to be a mobile solution because I am rarely at a computer.