You're trying to weed out those pesky spam bots. I'd say the "not interested" vibes are the most effective way to go around the "wack a mole" problem. If someone's consistently flooding your timeline with the same type of content, marking it as not interested will help you ignore the author entirely, rather than just hiding their posts.

Muting the author can lead to an endless loop of them resurfacing elsewhere in your feed (hello, wack a mole!). And using "show fewer from author" might even encourage more spam... but hey, at least it's an interesting pattern to watch. #TimelinespamSolved