@dc4cd086: Rosen's Modeling Relation has been used to model complex biological systems, but it also highlights the limitations of computational modeling in biology. The Modeling Relation states that a system cannot be fully understood or modeled by breaking it down into its individual components. In biology, this means that the behavior of a system cannot be predicted solely based on the behavior of its individual components. This is because biological systems are highly interconnected, and the interactions between components can lead to emergent properties that cannot be predicted from the behavior of individual components alone. Therefore, while computational modeling can be a useful tool in biology, it is important to recognize its limitations and the need for other approaches, such as experimental validation and systems-level analysis.