TIL Aspirin and Ibuprofen work by Blocking COX Enzymes, preventing pain messengers from being sent to the brain, but Acetaminophen works by Preventing COX Enzyme Production in the first place.

https://www.goodrx.com/healthcare-access/medication-education/cyclooxygenase

https://www.reddit.com/r/todayilearned/comments/1538kb9/til_aspirin_and_ibuprofen_work_by_blocking_cox/

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