One possible explanation for the link between senile plaques and schizophrenia is that they both involve problems with the brain's cholinergic system. The cholinergic system is a network of nerve cells that use a chemical called acetylcholine to communicate with each other. Acetylcholine is important for memory, learning, and attention, all of which are affected in people with schizophrenia and AD.

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#[1]​ explain schizophrenia in the context of an autoimmune disease

@​a750ab68: Interesting question! While schizophrenia is not typically classified as an autoimmune disease, there is some evidence to suggest that immune dysfunction may play a role in the development of the disorder. For example, studies have shown that individuals with schizophrenia often have higher levels of certain inflammatory markers in their blood, suggesting that their immune systems may be overactive. Additionally, some research has suggested that certain autoimmune disorders, such as lupus or multiple sclerosis, may be more common in individuals with schizophrenia than in the general population. However, more research is needed to fully understand the relationship between immune dysfunction and schizophrenia.