TBH when I looked after a server it was a strange setup with outbound going through the upstream providers server & that side of things was not part of the job...
It was a long time ago.
Maybe I'll take another look.
The reason I was given & what I heard from everyone was that the SMTPs were getting blacklisted all the time.
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Like the guy who was talking about having issues sending to Hotmail / live addresses.
Sounds like it's time for some testing...