Also, have you ever looked at https://moq.dev/ ?
I think it could be a really nice alternative to webrtc. It's far simpler and flexible. The best demo I made using it was https://github.com/justinmoon/av-demo. This does uses Marmot/Whitenoise encryption stack on audio calls. I think this would be a really nice stack for nostr a/v work.
Happy to collaborate if you're interested!