Amethyst for it's ability to set certain relays for certain things, built-in tor with fairly safe defaults using it for non-trusted relays, very wide note rendering support including pics, vids, emoji, lightning invoices, note deletions/edits and it's clean snappy UI.

Nostrudel for it's massive support of the most nips allowing it to be a one stop shop for everything nostr. Albeit a shitty UI.

Coracle for client side wot implementation.

Oxchat for the cleanest and most secure chat.

I'll throw in Primal and Yakihonne for search and simplicity even though they both rely on centralized services for that simplicity.