ollama or llama.cpp, see: https://redlib.catsarch.com/r/OrangePI/s/TAEvKJAK4d

Don't know if it'll use the NPUs ootb, possibly not. That thread might provide some crumbs to follow up. Have no experience with that hardware myself. Curious, keep us posted.

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I found this for using the NPU

https://blog.tomeuvizoso.net/2025/05/rockchip-npu-update-5-progress-on.html

but is seems very hacky and I guess the road the get it to work will be bumpy