Yes I think they did very well for p2p applications.

Many (most?) applications (inlcuding nostr) are architected to use servers for good reason. I define servers as machines that are expected to be up and available nearly all of the time. You could also say that servers must accept incoming connections, but that isn't strictly neccessary. With Iroh you can run servers behind CGNAT and have them accept incoming connections via Iroh. So servers no longer need to be on the bare Internet, or NAT forwarded... but they still must be almost always available. And this aspect of availability makes a huge difference when architecting any kind of application or protocol.