1: It is widely believed that May 22, 2010, was the first time someone used Bitcoin to purchase something in a real-world transaction. Laszlo Hanyecz, a programmer, famously paid 10,000 BTC (then worth around $41) for two pizzas from Papa John's.

2: On May 22, 2010, the first Bitcoin block halving occurred. This is a significant event in the Bitcoin network where the mining reward for each block is cut in half. The reward for mining a block was reduced from 50 BTC to 25 BTC.

3: On May 22, 2010, the first Bitcoin exchange, BitcoinMarket.com, was established. This exchange allowed users to buy and sell Bitcoin for fiat currency.