Rubio and the 12th amendment
Unless Rubio moves out of Florida and/or legally assumes residence in a state other than Florida he can’t be selected as President Trump’s vice presidential running mate. Trump is also a resident of Florida. It also assumes Rubio would resign from the Senate as Florida’s senior senator as he’d no longer be a resident of Florida and could no longer represent the citizens there.
I doubt this constitutional sleight of hand would go down well with lots of people even if he pulled it off.