Actually, all of these suggestions pale in comparison to an AR-15 or a shotgun for home defense, but you ideally want both, the pistol to lay down cover to get you to your rifle. Most anyone is more accurate and deadly with these, handguns take practice.
Glock 19 in 9mm all day long, stupid simple operation, no safeties to trip you up, not terribly hard to pull the slide back.
But if you want something you can take with you and put in a purse, or conceal on your body, smith and Wesson m&p shield 9mm performance center.
https://www.smith-wesson.com/product/performance-center-m-p-9-shield-plus-with-carry-kit
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