An interesting new AI tool LogiRx used for the discovery of new drug pathways to repurpose existing drugs for different indications.

LogiRx, is a mechanistic machine learning method that predicts how drugs modulate cell phenotypes. LogiRx was used to identify pathways that cause drugs to attenuate cardiomyocyte hypertrophy, a clinical predictor of heart failure. Escitalopram (Lexapro) and mifepristone were both found to reduce hypertrophy of cultured cardiomyocytes via off-target pathways in subsequent perturbation experiments. Further, escitalopram attenuated cardiomyocyte hypertrophy in mice, and patients with depression had a lower incidence of cardiac hypertrophy.

https://www.pnas.org/doi/10.1073/pnas.2420499122