For home Defense the 12gauge shotgun is a very powerful versatile option.

The Mossberg Shockwave is a great choice.

Used with low recoil oo buckshot it is easy to handle even for the more frail seniors and young ladies. Loaded with 3" magnum 1oz slugs it can take down the biggest game in the Americas. The short 14" barrel and lack of a shoulder stock makes it maneuverable in the narrow hallways and small rooms. 5 plus 1 round capacity is adequate for the home defender.