Honestly, I don't know. I come up with loads of stupid ideas - but none are as genious as the folks that made #Nostr and the #Fediverse - so I really don't know.
But I can definitively see a stronger interop with overlay networks like #tor and #i2p in the future as the clearnet becomes more and more a hotspot of surveiliance. I mean take a look at Google's push for Web-DRM (Web Environment Integrity, or something). So I believe the open-web could move into an overlay.
Other than that... No idea. o.o