Just to timestamp this -- I switched from the Chiefs to the Lions (line is 6.5) in my home pool with no Chris Jones or Travis Kelce. I didn't use the pick in any of my three faux (online) Super Contest entries where the line is down to 4.5.
Kind of torn whether to use Skyy Moore in a league with Kelce out, but that Kadarius Toney is playing, and we really have no idea, I'll probably sit him for someone like Michael Thomas or Kyle Pitts.