Pixelfed ships with a list of blocked email providers, mostly consisting of anonymous providers.
This works pretty good, though I need to update the list and allow admins to define their own, as well as disable it altogether.
Pixelfed does things a bit different, pushing boundaries and setting trends when it comes to dealing with spam feels pretty cool 😎
https://github.com/pixelfed/pixelfed/blob/dev/app/Services/EmailService.php#L20