Won't impact system files and change what qemu guest agent reports?
Discussion
Well like all of those takeover scripts it just changes the system files. The only special thing is that it autogenerates a configuration\.nix file with networking stuff and public keys.
Pretty neat though. Would be nice if NixOS devs decided to create their own cloudinit images.
P.S. You should take a look at this https://bsd-cloud-image.org/