If Mike McCulloch's theory of Quantised Inertia works out in practical experiments then we can ditch dark matter and a new era of interstellar travel will become a possibility.

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Even if we devise ways of moving stuff across the stars at reasonable speeds, I still think our bodies are just not made for it and the only way we can join our silicon-based inventions in interstellar travel and colonization is by embedding ourselves in them, preferably with zero organic parts.