I do not see how it is possible to have long life without alcohol and tobacco, which have been part of human consumption for 10,000 years - longer than any substance ever ingested, smoked, etc., in human history.
Discussion
I don’t think those increase the life of humans in years, or prolonged it.
But it gave humans other things, like altering their perception or persona… this can be very enriching for the self.
Yes ingensting these toxins per say will work your system harder kill more cells and make life shorter. Like Bitcoin Its a time preference thing, are you here for a good time or a long time? I prefer to tread lightly now.