The next major class of weight loss medications will likely be ones that accelerate metabolism.

This interesting study looked at HU6, a controlled metabolic accelerator that reduces adipose tissue, in heart failure (HFpEF) patients and found that it led to a statistically significant reduction in body weight, total fat mass, and visceral adiposity while sparing skeletal muscle but did not significantly improve peak volume of oxygen consumption.

https://jamanetwork.com/journals/jamacardiology/article-abstract/2831126