Premiere Pro exports are too big to be useful - takes ages to upload.
I use Handbrake (FOSS) for video compression & encoding. It takes some stuffing around to get the settings right but then you have a preset that is reusable. Much better compression than any Adobe solution & most others I've found.
I wouldn't go over 720p res for Nostr vids (most people are using their phones anyway). Just downloading from YouTube at 720p gets me a 180MB file. I uploaded this download to Nostr build (I have a sub).
https://v.nostr.build/wQEJ.mp4