I plan on using it for NCD media. I have never used self hosted S3 so this will surely prove a challenge.
Discussion
It's not that bad, and you should be fine if you're just directly connecting the S3 server to the NCD server or even running them on the same machine. If you're tunneling over VLANs and VPNs through several servers though, which I doubt you are, you can have issues unless you configure everything right.