It means that the NIP-05 is not valid.
nostr:npub180cvv07tjdrrgpa0j7j7tmnyl2yr6yr7l8j4s3evf6u64th6gkwsyjh6w6 nostr:npub10000003zmk89narqpczy4ff6rnuht2wu05na7kpnh3mak7z2tqzsv8vwqk I am troubleshooting https://github.com/nostrability/nostrability/issues/174
What does a strikethrough mean?

Discussion
How do you determine this?
What are the downstream effects for nostr apps of a broken nip-05?
https://github.com/nostr-protocol/nips/blob/master/05.md explains a lot of things.
Apart from the fact that the specific case is formally invalid, since it is not an address (user@domain.com), to check whether a NIP-05 is valid, it is necessary to retrieve some data from an endpoint and check whether the npub matches.
Nostr applications do not suffer in any way from an invalid NIP-05; it should be considered by the user as a red flag since it is often (but not always) related to impersonation.