There are indexeddb adapters for loki you can use. I eventually moved away from both loki and dexie. I use in-memory data structures and sync periodically to indexeddb.
Iris uses LokiJS for in-memory storage and Dexie for persistence. Both are pretty good, but it's a bit of a hassle to have 2 databases. Could try sqlite wasm.
I wonder if also #nostrdb could be used on wasm and persisted on origin private filesystem like sqlite. https://sqlite.org/wasm/doc/trunk/persistence.md#opfs
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