Pay attention that vanity pub keys can be a security threat.

Someone can try to impersonate you simply mining the same prefix; users are inclined to check only the first/last parts of a key, a vanity one incentive this behaviour.

IMHO.

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They're no more of a threat than any non-vanity address would be. I could focus a search on any non-vanity address type if I wanted to impersonate someone else. I'd say this is the best reason for using NIP-05 address to help validate your account.