The last couple days were stressful, but here's where I landed:

- New motherboard and case in place

- Qubes 4.2 installed

- Data restored with minimal data loss

- Still having that same issue with hidraw devices!

Next steps:

1. Backup (properly this time!)

- fresh backup (in progress)

- verify integrity of backup

- copy backup to another physical drive

- verify integrity of the copy

- Repeat as needed until I am convinced I have two good copies of all my data

2. Boot Tails and verify this problem exists there too

3. Make a Qubes 4.1 installer

4. Install Qubes 4.1 and restore data

5. Re-test for hidraw filtering