Helenistic astrology => Torah/Kabbalah => modern science => transhumanism
I hate with all my core the concept of "the great work"
The beauty of complex life is the moving sand island in the turbulent river, it is not some platform game, where you go up levels.
Most cultures have a version of the Chakra meme, and talk of imbalances. That's the work - balance the chakras, not to race to the "crown" neglecting the others ( tower of babel )
Much of science is still based on a ~5000 old failed meme