Not really. The reason they are challenging to block on free relays is they can create infinite pubkeys. On nostr.wine each one they create is 18,888 sats. What good is that if everyone mutes you after day 1 of spamming?

Filter.nostr.wine addressed this with our Purgatory data pipeline (quite successfully) since it reads from free relays and does not have the same advantage as nostr.wine.