Absolutely, at least when using MyNode. I currently don’t do anything w/ my lightning node, running via MyNode, but all of my on-chain transactions go through my personal node.
BlueWallet is not as fast as the Trezor Suite, but I find it very usable. I run Orbot on my phone which routes my traffic through Tor. This works well for accessing my node remotely via Safari, or using BlueWallet in general.