The only natural way to avoid suffering, be happy, is to seek and achieve wisdom all the time. That is also a guaranteed way to make you very lonely. The wiser and happier you are the lonelier it gets. There is no avoiding this.

There is one unnatural way, though. You do not get the wisdom but you can get the happiness. You can stick with one of the religions that deliver that. But you really have to be a devoted blind believer then. I would suggest Islam or one of the Japanese, although others might get you that , too. But be aware that this is not only a no wisdom approach, but also a very selfish one. By doing this you turn yourself into a slave, drag others with you, and incentivise slave masters to exist.

If many many people chose the wisdom path, maybe, just maybe, it would eventually get less lovely for the wise ones.