I interact with plenty of accounts that are pseudonymous and have genderless names. So yes, in those cases I do. But it's irrelevant, so it's not a struggle by any means since I don't bother trying.
Discussion
Also, you can keep both your identity and location private.
That way, you don’t have to worry about threats of violence. You can just laugh at them.
Personally I don’t care about people’s identity or any personal characteristics. I don’t even care if they’re a human or not.