With curated relays.

A relay owner could potentially manually curate which npubs gets to write to that relay. That means if you only use that relay you would see a very curated timeline of manually picked people that are not bots or AI.

Of course it might not be feasible to do it, but it can be done already.

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Discussion

It seems that what you describe is a whitelist relay which may have interesting properties but probably not a good fit to act as a regular relay free of AIs.