nostr:npub1v0lxxxxutpvrelsksy8cdhgfux9l6a42hsj2qzquu2zk7vc9qnkszrqj49 The ability to write content will be affected way more than the ability to read content, thanks to NIP-65 regarding the latter.

This is why the write-side should aim to mitigate this by tracking uptime with a tool like nostr.watch, and intelligently rotating a users write-relays when some go down.