it causes HPPD too easily, it has too much vasoconstriction, and it lowers your seizure threshold too much. the therapeutic index is very narrow like LSD but unlike LSD taking too much can put your body in physical danger. it's also a full agonist at 5-HT receptor sites and this will likely cause some brain damage. it's fistfucking the receptor. you will notice when you take it that it makes your tolerance to other psychedelics very high for a much longer time than normal.