TIL prolonged use of beta 2 agonists in case of bronchial asthma can lead to down regulation of beta receptors.

https://pubmed.ncbi.nlm.nih.gov/1968733/

https://www.reddit.com/r/todayilearned/comments/152sdq2/til_prolonged_use_of_beta_2_agonists_in_case_of/