GPCR activation and GRK2 assembly by a biased intracellular agonist
Nature, Published online: 02 August 2023; doi:10.1038/s41586-023-06395-9Structural studies on the complex containing G-protein-coupled receptor kinase 2 (GRK2), neurotensin receptor 1 (NTSR1), Gαq and the arrestin-biased ligand SBI-553 provide insights into these interactions and a foundation for the design of arrestin-biased ligands for... #press
https://www.nature.com/articles/s41586-023-06395-9?utm_source=press.coop