TIL: During the 18 months of the Great Plague (1665-1666), Isaac Newton conceived calculus, set foundations for his theory of light and color, theory of gravity, worked on laws of planetary motion and wrote many papers creating the foundations of early calculus.
https://www.nysoclib.org/blog/newton%E2%80%99s-%E2%80%9Cyear-wonders%E2%80%9D-during-great-plague