"The observed extended presence of vaccine mRNA and spike protein in vaccinee LN GCs for up to 2 months after vaccination was in contrast to rare foci of viral spike protein in COVID-19 patient LNs. We hypothesize that the abundant spike antigen in the GCs of mRNA vaccine recipient LNs may contribute to the increased breadth of viral variant RBD binding by IgG seen after vaccination, potentially due to high antigen concentrations stimulating B cells with lower affinity for Wuhan-Hu-1 spike epitopes and better binding to variant epitopes."
Discussion
Thanks for sharing this—I was not aware of this data; this is very surprising and goes against common expectations for mRNA. This could explain the long-term T-cell tuning as well if the nanoparticles are accumulating stably in the lymph nodes. Very odd. The nano particles must be stable long term in certain tissues. If only we had undergone long-term safety testing. FFS 🤦♂️.
Check this one out about pseudouridine:
https://rwmalonemd.substack.com/p/when-is-mrna-not-really-mrna