Losing access to a metric shit ton of software when I left my position at Texas Tech . . . I knew it was going to suck but no amount of preparing yourself for the inevitable actually prepares yourself at all.
I used to build the computer image for our labs' computers and when I was done shoving all of our licensed software into it the SSD held something like 250 GB.
Matlab
Simulink
ESRI
The entire catalogs of Autodesk and Adobe
Unity, Houdini, Unreal Engine
The list goes on and on.
Fuuuuuuug . . .