The Vault—the most enigmatic structure in cell biology.
Often absent from science textbooks due to its mysterious nature, this giant, half-empty structure has puzzled researchers for 40 years. Found in nearly every cell of every animal on Earth, its true function remains largely unknown.
https://video.nostr.build/0186f34b3507c5ae8257f94d00606bdf090279afcd12e0b15d750cc0df5ebeae.mp4
AI answer for: Explore the theories and possible purposes of "The Vault" structure in cell biology. Also entertain mystical and esoteric interpretations.
https://www.perplexity.ai/search/explore-the-theories-and-possi-16E_afdCSRiEp1r.P3t5Gg#0
Weird! I know a couple folks in the medical field, I’d like to show this to them. Where did you get them reference for this?
Original Discovery:
Kedersha, N. L., & Rome, L. H. (1986). Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a small RNA and a major polypeptide of 104 kDa. The Journal of Cell Biology, 103(3), 699–709.
This paper introduced vaults to the scientific community.
Structure & Composition:
Anderson, D. H., et al. (2007). Three-dimensional structure of eukaryotic vaults. Nature, 386, 836-838.
Details on the unique barrel-like structure of vaults.
Potential Functions & Medical Relevance:
Steiner, E., et al. (2006). Major vault protein is a novel substrate of JNK and involved in multidrug resistance. The Journal of Biological Chemistry, 281(28), 19332-19339.
Connects vaults to drug resistance in cancer therapy.
Berger, W., et al. (2009). Vaults and the major vault protein: novel roles in signal pathway regulation and immunity. Cellular and Molecular Life Sciences, 66(1), 43–61.
Discusses vaults in immune function and cellular signaling.
These should provide a solid foundation if your contacts want to dig deeper! If they need a more general summary, they can also check NCBI, ScienceDirect, or Nature Reviews for articles on vault proteins.
This is amazing stuff! Thank you for providing the references.
